Metformin drugs are used for type 2 diabetes patients. At present, a new study by a team of experts from Cardiff University in the United Kingdom reveals that this drug has a surprising effect, namely extending the life of someone who is not diabetic.
According to the CDC, there are around 9.3 percent of the world's population with diabetes. Diabetes is usually associated with old age, obesity, lack of physical activity, and family history of diabetes.
Disease can be prevented by eating healthy food, regular physical activity, and reducing excess weight. People with diabetes must make some of these efforts to control their symptoms, but sometimes they still need insulin or drinking drugs for their diabetes.
Overview of the metformin drug
Metformin is a biguanide drug for the treatment of diabetes, a condition in which the body cannot use or produce insulin normally. Insulin is a hormone that is responsible for converting sugar into energy. Insulin deficiency means that sugar will only accumulate in the blood, not be converted into energy.
Well, this diabetes drug helps control the amount of sugar or glucose in your blood. You do this by reducing the amount of absorption of glucose from food consumed and reducing the amount of glucose formed by your liver. This drug also increases the body's natural response to produce insulin which can help control the amount of sugar in the blood.
Is it true that metformin drugs can make you live longer?
A large-scale study involving more than 180,000 people compared the survival rates of diabetic patients treated with metformin and sulfonylurea drugs. The study also involved people who did not have diabetes.
The study found 78,241 patients treated with metformin, 12,222 patients treated with sulfonylureas, and as many as 90,463 people without diabetes as a comparison or control group. During the study, there were 7,498 deaths.
Diabetes is estimated to reduce the patient's life expectancy by an average of about eight years. However, the researchers found that metformin drug users lived 15 percent longer (equivalent to an additional age of 3 years) compared to those in the control group, while patients treated with sulfonylurea drugs had lower life expectancies compared to the control group.
Another study conducted by the National Institute of Aging found that mice given metformin drugs could live five percent longer than mice that did not get metformin.
Mice given metformin are also physically healthier at old age and are less likely to get cataracts when compared to mice that don't get metformin.
How can metformin drugs make longevity?
Researchers say that metformin seems to have effects such as reducing cholesterol levels and activating or deactivating certain genes. Metformin drugs also increase the antioxidant response in animals and reduce inflammation, which might contribute to the effect of increasing life expectancy.
I don't have diabetes, can I take metformin medicine for longevity?
This drug is not recommended for consumption without the supervision of a doctor, especially for the long term. Especially those of you who do not have diabetes, this drug will actually provide a variety of side effects that are not good for the body, rather than providing longevity benefits.
Because this drug is responsible for triggering the work of insulin in the body, you might even experience an insulin overdose, which is when there is too much insulin in the body. This condition is also called hyperinsulinemia. This condition can increase the risk of inflammation in the body to diseases such as gout and hypertension (high blood pressure).
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